Insulin‐like growth factor‐I gene therapy increases hippocampal neurogenesis, astrocyte branching and improves spatial memory in female aging rats

Pardo, Joaquín; Uriarte, Maia; M. Cónsole, Gloria; C. Reggiani, Paula; F. Outeiro, Tiago; R. Morel, Gustavo; G. Goya, Rodolfo

doi:10.1111/ejn.13278

Public

Insulin‐like growth factor‐I gene therapy increases hippocampal neurogenesis, astrocyte branching and improves spatial memory in female aging rats

Published in European Journal of Neuroscience • May 18, 2016

Authors:

Joaquín Pardo

Maia Uriarte

Gloria M. Cónsole

Abstract

In rats, learning and memory performance decline during aging, which makes this rodent species a suitable model to evaluate therapeutic strategies of potential value for correcting age-related cognitive deficits. Some of these strategies involve neurotrophic factors like insulin-like growth factor-I...

Subject

Neurogenesis

Hippocampal formation

Astrocyte

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!