High incidence of chromosomal imbalances and gene amplifications in the classical follicular variant of follicle center lymphoma

Bentz, Martin; Werner, CA; Döhner, Hartmut; Joos, Stefan; Barth, TF; Siebert, Reiner; Schröder, Martin; Stilgenbauer, Stephan; Fischer, Konstanze; Mӧller, Peter; Lichter, Peter

doi:10.1182/blood.v88.4.1437.bloodjournal8841437

Public

High incidence of chromosomal imbalances and gene amplifications in the classical follicular variant of follicle center lymphoma

Published in Blood • Aug 15, 1996

Authors:

Martin Bentz

CA Werner

Hartmut Döhner

Abstract

The classical follicular variant of follicle center lymphoma (FCL-fo) is associated with the chromosomal translocation t(14;18)(q32;q21). However, the sole presence of this translocation is not sufficient for malignant transformation, as demonstrated by experiments in a transgenic mouse model. Most ...

Subject

Comparative genomic hybridization

Chromosomal translocation

Follicular lymphoma

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