Homology-directed repair in rodent zygotes using Cas9 and TALEN engineered proteins

Ménoret, Séverine; De Cian, Anne; Tesson, Laurent; Remy, Séverine; Usal, Claire; Boulé, Jean-Baptiste; Boix, Charlotte; Fontanière, Sandra; Crénéguy, Alison; H. Nguyen, Tuan; Brusselle, Lucas; Thinard, Reynald; Gauguier, Dominique; Concordet, Jean‐Paul; Chérifi, Yacine; Fraichard, Alexandre; Giovannangeli, Carine; Anegón, Ignacio

doi:10.1038/srep14410

Public

Homology-directed repair in rodent zygotes using Cas9 and TALEN engineered proteins

Published in Scientific Reports • Oct 7, 2015

Authors:

Séverine Ménoret

Anne De Cian

Laurent Tesson

Abstract

The generation of genetically-modified organisms has been revolutionized by the development of new genome editing technologies based on the use of gene-specific nucleases, such as meganucleases, ZFNs, TALENs and CRISPRs-Cas9 systems. The most rapid and cost-effective way to generate genetically-modi...

Subject

Transcription activator-like effector nuclease

Cas9

Genome editing

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