Pharmacokinetics and Pharmacodynamics of Extended Infusion Versus Short Infusion Piperacillin-Tazobactam in Critically Ill Patients Undergoing CRRT

S. Shotwell, Matthew; Nesbitt, Ross; Madonia, Phillip; Gould, Edward; Connor, Michael; Salem, Charbel; A. Aduroja, Olufemi; Amde, Milen; J. Groszek, Joseph; Wei, Peilin; E. Taylor, Maria; Tolwani, Ashita; H. Fissell, William

doi:10.2215/cjn.10260915

Public

Pharmacokinetics and Pharmacodynamics of Extended Infusion Versus Short Infusion Piperacillin-Tazobactam in Critically Ill Patients Undergoing CRRT

Published in Clinical Journal of the American Society of Nephrology • May 19, 2016

Authors:

Matthew S. Shotwell

Ross Nesbitt

Phillip Madonia

Abstract

BACKGROUND AND OBJECTIVES: Infection is the most common cause of death in severe AKI, but many patients receiving continuous RRT do not reach target antibiotic concentrations in plasma. Extended infusion of β-lactams is associated with improved target attainment in critically ill patients; thus, we ...

Subject

Medicine

Piperacillin/tazobactam

Critically ill

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