Nicotinamide Riboside Opposes Type 2 Diabetes and Neuropathy in Mice

A.J. Trammell, Samuel; J. Weidemann, Benjamin; Chadda, Ankita; S. Yorek, Matthew; Holmes, Amey; J. Coppey, Lawrence; Obrosov, Alexander; H. Kardon, Randy; A. Yorek, Mark; Brenner, Charles

doi:10.1038/srep26933

Public

Nicotinamide Riboside Opposes Type 2 Diabetes and Neuropathy in Mice

Published in Scientific Reports • May 27, 2016

Authors:

Samuel A.J. Trammell

Benjamin J. Weidemann

Ankita Chadda

Abstract

Male C57BL/6J mice raised on high fat diet (HFD) become prediabetic and develop insulin resistance and sensory neuropathy. The same mice given low doses of streptozotocin are a model of type 2 diabetes (T2D), developing hyperglycemia, severe insulin resistance and diabetic peripheral neuropathy invo...

Subject

Internal medicine

Endocrinology

Insulin resistance

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