Modulation of Hypoxia in Solid Tumor Microenvironment with MnO<sub>2</sub> Nanoparticles to Enhance Photodynamic Therapy

Zhu, Wenwen; Dong, Ziliang; Fu, Tingting; Liu, Jingjing; Chen, Qian; Li, Yanguang; Zhu, Ran; Xu, Ligeng; Liu, Zhuang

doi:10.1002/adfm.201600676

Public

Modulation of Hypoxia in Solid Tumor Microenvironment with MnO2 Nanoparticles to Enhance Photodynamic Therapy

Published in Advanced Functional Materials • May 20, 2016

Authors:

Wenwen Zhu

Ziliang Dong

Tingting Fu

Abstract

Hypoxia not only promotes tumor metastasis but also strengthens tumor resistance to therapies that demand the involvement of oxygen, such as radiation therapy and photodynamic therapy (PDT). Herein, taking advantage of the high reactivity of manganese dioxide (MnO 2 ) nanoparticles toward endogenous...

Subject

Tumor hypoxia

Tumor microenvironment

Materials science

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