Surface Functionalization of Nanoparticles with Polyethylene Glycol: Effects on Protein Adsorption and Cellular Uptake

Pelaz, Beatriz; del Pino, Pablo; Maffre, Pauline; Hartmann, Raimo; Gallego, Marta; Rivera‐Fernández, Sara; M. de la Fuente, Jesús; Ulrich Nienhaus, G.; J. Parak, Wolfgang

doi:10.1021/acsnano.5b01326

Public

Surface Functionalization of Nanoparticles with Polyethylene Glycol: Effects on Protein Adsorption and Cellular Uptake

Published in ACS Nano • Jun 16, 2015

Authors:

Beatriz Pelaz

Pablo del Pino

Pauline Maffre

Abstract

Here we have investigated the effect of enshrouding polymer-coated nanoparticles (NPs) with polyethylene glycol (PEG) on the adsorption of proteins and uptake by cultured cells. PEG was covalently linked to the polymer surface to the maximal grafting density achievable under our experimental conditi...

Subject

PEGylation

Polyethylene glycol

Adsorption

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