Tumor-derived exosomes regulate expression of immune function-related genes in human T cell subsets

Müller, Laurent; Mitsuhashi, Masato; Simms, Patricia; E. Gooding, William; L. Whiteside, Theresa

doi:10.1038/srep20254

Public

Tumor-derived exosomes regulate expression of immune function-related genes in human T cell subsets

Published in Scientific Reports • Feb 4, 2016

Authors:

Laurent Müller

Masato Mitsuhashi

Patricia Simms

Abstract

Tumor cell-derived exosomes (TEX) suppress functions of immune cells. Here, changes in the gene profiles of primary human T lymphocytes exposed in vitro to exosomes were evaluated. CD4(+) Tconv, CD8(+) T or CD4(+) CD39(+) Treg were isolated from normal donors' peripheral blood and co-incubated with ...

Subject

Microvesicles

Immune system

Biology

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