Effect of miR-34a in regulating steatosis by targeting PPARα expression in nonalcoholic fatty liver disease

Ding, Jiexia; Li, Meng; Wan, Xingyong; Jin, Xi; Chen, Shaohua; Yu, Chaohui; Li, Youming

doi:10.1038/srep13729

Public

Effect of miR-34a in regulating steatosis by targeting PPARα expression in nonalcoholic fatty liver disease

Published in Scientific Reports • Sep 2, 2015

Authors:

Jiexia Ding

Meng Li

Xingyong Wan

Abstract

MicroRNA-34a (miR-34a) is thought to be involved in nonalcoholic fatty liver disease (NAFLD). However, the association between altered expression of miR-34a and the pathophysiological features of NAFLD remains unclear. Here, we investigated the mechanisms by which miR-34a influences NAFLD through th...

Subject

Nonalcoholic fatty liver disease

Downregulation and upregulation

Steatosis

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