Analytical validation of a standardized scoring protocol for Ki67: phase 3 of an international multicenter collaboration

Leung, Samuel; O. Nielsen, Torsten; Zabaglo, Lila; Arun, Indu; Badve, Sunil; Bane, Anita; M.S. Bartlett, John; Borgquist, Signe; C. Chang, Martin; Dodson, Andrew; A. Enos, Rebecca; Fineberg, Susan; M. Focke, Cornelia; Gao, Dongxia; M. Gown, Allen; Grabau, Dorthe; Gutiérrez, Carolina; Hugh, Judith; Kos, Zuzana; Lænkholm, Anne‐Vibeke; Lin, Minggang; G. Mastropasqua, Mauro; Moriya, Takuya; Nofech‐Mozes, Sharon; Kent Osborne, C.; Penault‐Llorca, Frédérique; Piper, Tammy; Sakatani, Takashi; Salgado, Roberto; Starczynski, Jane; Viale, Giuseppe; F. Hayes, Daniel; M. McShane, Lisa; Dowsett, Mitch; behalf of the International Ki67 in Breast Cancer Working Group of the Breast International Group and North American Breast Cancer Group (BIG-NABCG), on

doi:10.1038/npjbcancer.2016.14

Public

Analytical validation of a standardized scoring protocol for Ki67: phase 3 of an international multicenter collaboration

Published in npj Breast Cancer • May 17, 2016

Authors:

Samuel Leung

Torsten O. Nielsen

Lila Zabaglo

Abstract

Pathological analysis of the nuclear proliferation biomarker Ki67 has multiple potential roles in breast and other cancers. However, clinical utility of the immunohistochemical (IHC) assay for Ki67 immunohistochemistry has been hampered by unacceptable between-laboratory analytical variability. The ...

Subject

Intraclass correlation

External quality assessment

Reproducibility

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