Assessing the role of insulin‐like growth factors and binding proteins in prostate cancer using Mendelian randomization: Genetic variants as instruments for circulating levels

Bonilla, Carolina; J. Lewis, Sarah; Rowlands, Mari‐Anne; R. Gaunt, Tom; Davey Smith, George; Gunnell, David; Palmer, Tom; Donovan, Jenny; C. Hamdy, Freddie; E. Neal, David; A. Eeles, Rosalind; Easton, Doug; Kote‐Jarai, Zsofia; Amin Al Olama, Ali; Benlloch, Sara; Muir, Kenneth; G. Giles, Graham; Wiklund, Fredrik; Grönberg, Henrik; A. Haiman, Christopher; Schleutker, Johanna; G. Nordestgaard, Børge; C. Travis, Ruth; Pashayan, Nora; Khaw, Kay‐Tee; L. Stanford, Janet; J. Blot, William; N. Thibodeau, Stephen; Maier, Christiane; S. Kibel, Adam; Cybulski, Cezary; Cannon‐Albright, Lisa; Brenner, Hermann; Moon Park, Jong; Kaneva, Radka; Batra, Jyotsna; R. Teixeira, Manuel; Pandha, Hardev; Lathrop, Mark; M. Martin, Richard; M.P. Holly, Jeff

doi:10.1002/ijc.30206

Public

Assessing the role of insulin‐like growth factors and binding proteins in prostate cancer using Mendelian randomization: Genetic variants as instruments for circulating levels

Published in International Journal of Cancer • May 26, 2016

Authors:

Carolina Bonilla

Sarah J. Lewis

Mari‐Anne Rowlands

Abstract

Circulating insulin-like growth factors (IGFs) and their binding proteins (IGFBPs) are associated with prostate cancer. Using genetic variants as instruments for IGF peptides, we investigated whether these associations are likely to be causal. We identified from the literature 56 single nucleotide p...

Subject

Mendelian randomization

Prostate cancer

Insulin-like growth factor-binding protein

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