Tumor-Infiltrating Lymphocytes: A Predictive and Prognostic Biomarker in Neoadjuvant-Treated HER2-Positive Breast Cancer

Ingold Heppner, Barbara; Untch, Michael; Denkert, Carsten; M. Pfitzner, Berit; Lederer, Bianca; Schmitt, Wolfgang; Eidtmann, Holger; A. Fasching, Peter; Tesch, Hans; Solbach, Christine; Rezai, Mahdi; M. Zahm, Dirk; Holms, Frank; Glados, Manfred; Krabisch, Petra; Heck, Esther; Ober, Angelika; Lorenz, Petra; Diebold, Kurt; Habeck, Jörg-Olaf; Loibl, Sibylle

doi:10.1158/1078-0432.ccr-15-2338

Public

Tumor-Infiltrating Lymphocytes: A Predictive and Prognostic Biomarker in Neoadjuvant-Treated HER2-Positive Breast Cancer

Published in Clinical Cancer Research • May 17, 2016

Authors:

Barbara Ingold Heppner

Michael Untch

Carsten Denkert

Abstract

PURPOSE: We elucidated the value of tumor-infiltrating lymphocytes (TIL) as an independent predictor for pathologic complete response (pCR) rate and as a prognostic marker for disease-free survival (DFS) in patients with HER2-positive breast cancer in the neoadjuvant setting. EXPERIMENTAL DESIGN: We...

Subject

Breast cancer

Medicine

Biomarker

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