Serum hepatitis B virus RNA is encapsidated pregenome RNA that may be associated with persistence of viral infection and rebound

Wang, Jie; Shen, Tao; Huang, Xiangbo; Renuka Kumar, G.; Chen, Xiangmei; Zeng, Zhenzhen; Zhang, Ruiyang; Chen, Ran; Li, Tong; Zhang, Tianying; Yuan, Quan; Li, Pao-Chen; Huang, Qi; J. Colonno, Richard; Jia, Jidong; Hou, Jinlin; A. McCrae, Malcolm; Gao, Zhiliang; Ren, Hong; Xia, Ningshao; Zhuang, Hui; Lu, Fengmin

doi:10.1016/j.jhep.2016.05.029

Public

Serum hepatitis B virus RNA is encapsidated pregenome RNA that may be associated with persistence of viral infection and rebound

Published in Journal of Hepatology • May 29, 2016

Authors:

Jie Wang

Tao Shen

Xiangbo Huang

Abstract

BACKGROUND & AIMS: Hepatitis B virus (HBV) RNA in serum has recently been linked to efficacy and prognosis of chronic hepatitis B (CHB) treatment. This study explored the nature, origin, underlying mechanisms, and potential clinical significance of serum HBV RNA. METHODS: The levels of HBV DNA and R...

Subject

Persistence (discontinuity)

Virology

RNA

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