Histamine induces microglia activation and dopaminergic neuronal toxicity via H1 receptor activation

M. Rocha, Sandra; Saraiva, Tatiana; Clara Cristóvão, Ana; Ferreira, Raquel; Santos, Tiago; Esteves, Marta; Saraiva, Cláudia; Je, Goun; Cortes, Luísa; Valero, Jorge; Alves, Gilberto; L. Klibanov, Alexander; Kim, Yoon-Seong; Bernardino, Liliana

doi:10.1186/s12974-016-0600-0

Public

Histamine induces microglia activation and dopaminergic neuronal toxicity via H1 receptor activation

Published in Journal of Neuroinflammation • Jun 3, 2016

Authors:

Sandra M. Rocha

Tatiana Saraiva

Ana Clara Cristóvão

Abstract

BACKGROUND: Histamine is an amine widely known as a peripheral inflammatory mediator and as a neurotransmitter in the central nervous system. Recently, it has been suggested that histamine acts as an innate modulator of microglial activity. Herein, we aimed to disclose the role of histamine in micro...

Subject

Histamine

Apocynin

Histaminergic

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