T-bet Activates Th1 Genes through Mediator and the Super Elongation Complex

Hertweck, Arnulf; M. Evans, C.; Eskandarpour, Malihe; C. Lau, Jonathan; Oļeiņika, Kristīne; Jackson, Ian; Kelly, Audrey; C. Ambrose, John; Adamson, Peter; J. Cousins, David; Lavender, Paul; L. Calder, Virginia; M. Lord, Graham; G. Jenner, Richard

doi:10.1016/j.celrep.2016.05.054

Public

T-bet Activates Th1 Genes through Mediator and the Super Elongation Complex

Published in Cell Reports • Jun 1, 2016

Authors:

Arnulf Hertweck

C. M. Evans

Malihe Eskandarpour

Abstract

The transcription factor T-bet directs Th1 cell differentiation, but the molecular mechanisms that underlie this lineage-specific gene regulation are not completely understood. Here, we show that T-bet acts through enhancers to allow the recruitment of Mediator and P-TEFb in the form of the super el...

Subject

Mediator

Elongation

Gene

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