Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body β-hydroxybutyrate

F. Sleiman, Sama; Henry, Jeffrey; Al-Haddad, Rami; El Hayek, Lauretta; Abou Haidar, Edwina; Stringer, Thomas; Ulja, Devyani; S. Karuppagounder, Saravanan; B. Holson, Edward; R. Ratan, Rajiv; Ninan, Ipe; V. Chao, Moses

doi:10.7554/elife.15092

Public

Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body β-hydroxybutyrate

Published in eLife • Jun 2, 2016

Authors:

Sama F. Sleiman

Jeffrey Henry

Rami Al-Haddad

Abstract

Exercise induces beneficial responses in the brain, which is accompanied by an increase in BDNF, a trophic factor associated with cognitive improvement and the alleviation of depression and anxiety. However, the exact mechanisms whereby physical exercise produces an induction in brain Bdnf gene expr...

Subject

Tropomyosin receptor kinase B

Neurotrophic factors

Brain-derived neurotrophic factor

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