A genomic approach to therapeutic target validation identifies a glucose-lowering <i>GLP1R</i> variant protective for coronary heart disease

A. Scott, Robert; F. Freitag, Daniel; Li, Li; Y. Chu, Audrey; Surendran, Praveen; Young, Robin; Grarup, Niels; Stančáková, Alena; Chen, Yuning; V. Varga, Tibor; Yaghootkar, Hanieh; Luan, Jian’an; Zhao, Wei; M. Willems, Sara; Wessel, Jennifer; Wang, Shuai; M. Maruthur, Nisa; Michailidou, Kyriaki; Pirie, Ailith; J. van der Lee, Sven; Gillson, Christopher; Amin Al Olama, Ali; Amouyel, Philippe; Arriola, Larraitz; Arveiler, Dominique; Avilés-Olmos, Icíar; Balkau, Beverley; Barricarte, Aurelio; Barroso, Inês; Benlloch Garcia, Sara; C. Bis, Joshua; Blankenberg, Stefan; Boehnke, Michael; Boeing, Heiner; Boerwinkle, Eric; B. Borecki, Ingrid; Bork‐Jensen, Jette; Bowden, S.; Caldas, Carlos; Caslake, Muriel; Adrienne Cupples, L.; Cruchaga, Carlos; Czajkowski, Jacek; den Hoed, Marcel; Dunn, Janet; Earl, Helena; Ehret, Georg; Ferrannini, Ele; Ferrières, Jean; Foltynie, Thomas; Ford, Ian; G. Forouhi, Nita; Gianfagna, Francesco; A. González, Carlos; Grioni, Sara; Hiller, Louise; Jansson, Jan‐Håkan; E. Jørgensen, Marit; Wouter Jukema, J.; Kaaks, Rudolf; Kee, Frank; D. Kerrison, Nicola; J. Key, Timothy; Kontto, Jukka; Kote‐Jarai, Zsofia; T. Kraja, Aldi; Kuulasmaa, Kari; Kuusisto, Johanna; Linneberg, Allan; Liu, Chunyu; Marenne, Gaëlle; L. Mohlke, Karen; P. Morris, Andrew; Muir, Kenneth; Müller‐Nurasyid, Martina; B. Munroe, Patricia; Navarro, Carmen; F. Nielsen, Sune; M. Nilsson, Peter; G. Nordestgaard, Børge; J. Packard, Chris; Palli, Domenico; Panico, Salvatore; M. Peloso, Gina; Perola, Markus; Peters, Annette; Poole, Christopher; Ramón Quirós, J.; Rolandsson, Olov; Sacerdote, Carlotta; Salomaa, Veikko; Sánchez, María‐José; Sattar, Naveed; J. Sharp, Stephen; Sims, Rebecca; Slimani, Nadia; A. Smith, Jennifer; J. Thompson, Deborah; Trompet, Stella; ­Tumino, ­Rosario; L. van der A, Daphne; T. van der Schouw, Yvonne; Virtamo, Jarmo; Walker, Mark; Walter, Klaudia; Working Group of the Cohorts for Heart, Neurology; Prospective Investigation into Cancer and Nutrition–Cardiovascular Disease (EPIC-CVD), European; , EPIC-InterAct; Abraham, Jean; T. Ámundadóttir, Laufey; L. Aponte, Jennifer; S. Butterworth, Adam; Dupuis, Josée; F. Easton, Douglas; A. Eeles, Rosalind; Erdmann, Jeanette; W. Franks, Paul; M. Frayling, Timothy; Hansen, Torben; M. M. Howson, Joanna; Jørgensen, Torben; S. Kooner, Jaspal; Laakso, Markku; Langenberg, Claudia; I. McCarthy, Mark; S. Pankow, James; Pedersen, Oluf; Ríboli, Elio; I. Rotter, Jerome; Saleheen, Danish; J. Samani, Nilesh; Schunkert, Heribert; Vollenweider, Péter; O’Rahilly, Stephen; Deloukas, Panos; Danesh, John; O. Goodarzi, Mark; Kathiresan, Sekar; B. Meigs, James; G. Ehm, Margaret; J. Wareham, Nicholas; Waterworth, Dawn

doi:10.1126/scitranslmed.aad3744

Public

A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease

Published in Science Translational Medicine • Jun 1, 2016

Authors:

Robert A. Scott

Daniel F. Freitag

Li Li

Abstract

Regulatory authorities have indicated that new drugs to treat type 2 diabetes (T2D) should not be associated with an unacceptable increase in cardiovascular risk. Human genetics may be able to guide development of antidiabetic therapies by predicting cardiovascular and other health endpoints. We the...

Subject

Medicine

Internal medicine

Disease

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