The <i>α</i>/<i>β</i> hydrolase fold

L. Ollis, David; Cheah, Eong; Cygler, Mirosław; W. Dijkstra, Bauke; Frolow, Felix; Franken, Sybille; Harel, Michal; Jamse Remington, S.; Silman, Israel; D. Schrag, Joseph; L. Sussman, Joel; H. G. Verschueren, Koen; Goldman, Adrian

doi:10.1093/protein/5.3.197

Public

The α/β hydrolase fold

Published in Protein Engineering Design and Selection • Jan 1, 1992

Authors:

David L. Ollis

Eong Cheah

Mirosław Cygler

Abstract

We have identified a new protein fold--the alpha/beta hydrolase fold--that is common to several hydrolytic enzymes of widely differing phylogenetic origin and catalytic function. The core of each enzyme is similar: an alpha/beta sheet, not barrel, of eight beta-sheets connected by alpha-helices. The...

Subject

Catalytic triad

Serine

Histidine

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