Safe long-term repeated disruption of the blood-brain barrier using an implantable ultrasound device: a multiparametric study in a primate model

Horodyckid, Catherine; Canney, Michael; Vignot, Alexandre; Boisgard, Raphaël; Drier, A.; Huberfeld, Gilles; François, Chantal; Prigent, Annick; Santin, Mathieu; Adam, Clovis; Willer, Jean‐Claude; Lafon, Cyril; Chapelon, Jean‐Yves; Carpentier, Alexandre

doi:10.3171/2016.3.jns151635

Public

Safe long-term repeated disruption of the blood-brain barrier using an implantable ultrasound device: a multiparametric study in a primate model

Published in Journal of neurosurgery • Jun 10, 2016

Authors:

Catherine Horodyckid

Michael Canney

Alexandre Vignot

Abstract

OBJECTIVE The main limitation to the efficacy of chemotherapy for brain tumors is the restricted access to the brain because of the limited permeability of the blood-brain barrier (BBB). Previous animal studies have shown that the application of pulsed ultrasound (US), in combination with the intrav...

Subject

Microbubbles

Medicine

Primate

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