Obesity-Induced Inflammation and Desmoplasia Promote Pancreatic Cancer Progression and Resistance to Chemotherapy

Incio, João; Liu, Hao; Suboj, Priya; M. Chin, Shan; X. Chen, Ivy; Pinter, Matthias; Rosa Ng, Mei; T. Nia, Hadi; Grahovac, Jelena; Kao, Shannon; Babykutty, Suboj; Huang, Yuhui; Jung, Keehoon; N. Rahbari, Nuh; Han, Xiaoxing; P. Chauhan, Vikash; D. Martin, John; Kahn, Julia; Huang, Peigen; Desphande, Vikram; Michaelson, James; Michelakos, Theodoros; R. Ferrone, Cristina; Soares, Raquel; Boucher, Yves; Fukumura, Dai; K. Jain, Rakesh

doi:10.1158/2159-8290.cd-15-1177

Public

Obesity-Induced Inflammation and Desmoplasia Promote Pancreatic Cancer Progression and Resistance to Chemotherapy

Published in Cancer Discovery • May 31, 2016

Authors:

João Incio

Hao Liu

Priya Suboj

Abstract

UNLABELLED: It remains unclear how obesity worsens treatment outcomes in patients with pancreatic ductal adenocarcinoma (PDAC). In normal pancreas, obesity promotes inflammation and fibrosis. We found in mouse models of PDAC that obesity also promotes desmoplasia associated with accelerated tumor gr...

Subject

Desmoplasia

Pancreatic cancer

Cancer

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