Azomethine Ylides from Nitrones: Using Catalytic nBuLi for the Totally Stereoselective Synthesis of trans-2-Alkyl-3-oxazolines.

V, Juste-Navarro; I, Delso; T, Tejero; P, Merino

doi:10.1002/chem.201602159

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Azomethine Ylides from Nitrones: Using Catalytic nBuLi for the Totally Stereoselective Synthesis of trans-2-Alkyl-3-oxazolines.

Shared by NobleBlocks on Jun 30, 2016 • 12:00 AM UTC

Authors:

Juste-Navarro V

Delso I

Tejero T

Abstract

The cycloaddition of azomethine ylide N-oxides (nitrone ylides) with aldehydes provides 3-oxazolines in a completely stereoselective manner in the presence of a catalytic amount of n-butyllithium. The process involves an initial nucleophilic attack on the aldehyde, followed by intramolecular oxygen ...

Subject

lithium

Nitrones

Density Functional Calculations

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