LncRNA HULC enhances epithelial-mesenchymal transition to promote tumorigenesis and metastasis of hepatocellular carcinoma via the miR-200a-3p/ZEB1 signaling pathway.

Shi-Peng, Li,; Hai-Xu, Xu,; Yao, Yu,; Jin-Dan, He,; Zhen, Wang,; Yan-Jie, Xu,; Chang-Ying, Wang,; Hai-Ming, Zhang,; Rong-Xin, Zhang,; Jian-Jun, Zhang,; Zhi, Yao,; Zhong-Yang, Shen,

doi:10.18632/oncotarget.9883

Public

LncRNA HULC enhances epithelial-mesenchymal transition to promote tumorigenesis and metastasis of hepatocellular carcinoma via the miR-200a-3p/ZEB1 signaling pathway.

Published in Oncotarget • Jul 5, 2016

Authors:

Li, Shi-Peng

Xu, Hai-Xu

Yu, Yao

Abstract

Highly upregulated in liver cancer (HULC), a lncRNA that is considered a key molecule in human liver cancer, has recently been revealed to be involved in hepatocellular carcinoma (HCC) development and progression [1, 2]. It has been reported that HULC can promote tumor invasion and metastasis of HCC...

Subject

ZEB1

epithelial-mesenchymal transition

hepatocellular carcinoma

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