ADAM30 Downregulates APP-Linked Defects Through Cathepsin D Activation in Alzheimer's Disease

Letronne, Florent; Laumet, Geoffroy; Ayral, Anne‐Marie; Chapuis, Julien; Demiautte, Florie; Laga, Mathias; E. Vandenberghe, Michel; Malmanche, Nicolas; Leroux, Florence; Eysert, Fanny; Sottejeau, Yoann; Chami, L.; Flaig, Amandine; Bauer, Charlotte; Dourlen, Pierre; Lesaffre, Marie; Delay, Charlotte; Huot, Ludovic; Dumont, Julie; Werkmeister, Elisabeth; Lafont, Franck; Mendes, Tiago; Hansmannel, Franck; Dermaut, Bart; Déprez, Benoît; Hérard, Anne‐Sophie; Dhénain, Marc; Souedet, Nicolas; Pasquier, Florence; Tulasne, David; Berr, Claudine; Hauw, Jean‐Jacques; Lemoine, Yves; Amouyel, Philippe; A. Mann, David; Deprez‐Poulain, Rebecca; Checler, Frédéric; Hot, David; Delzescaux, Thierry; Gevaert, Kris; Lambert, Jean‐Charles

doi:10.1016/j.ebiom.2016.06.002

Public

ADAM30 Downregulates APP-Linked Defects Through Cathepsin D Activation in Alzheimer's Disease

Published in EBioMedicine • Jun 3, 2016

Authors:

Florent Letronne

Geoffroy Laumet

Anne‐Marie Ayral

Abstract

Although several ADAMs (A disintegrin-like and metalloproteases) have been shown to contribute to the amyloid precursor protein (APP) metabolism, the full spectrum of metalloproteases involved in this metabolism remains to be established. Transcriptomic analyses centred on metalloprotease genes unra...

Subject

Cathepsin D

Amyloid precursor protein

Alzheimer's disease

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