Systematic Population Screening, Using Biomarkers and Genetic Testing, Identifies 2.5% of the U.K. Pediatric Diabetes Population With Monogenic Diabetes

Shepherd, Maggie; M. Shields, Beverley; Hammersley, Suzanne; Hudson, Michelle; J. McDonald, Timothy; Colclough, Kevin; A. Oram, Richard; Knight, Bridget; Hyde, Christopher; Cox, Julian; Mallam, Katherine; Moudiotis, Christopher; Smith, Rebecca; Fraser, Barbara; Robertson, Simon; Greene, Stephen; Ellard, Sian; R. Pearson, Ewan; T. Hattersley, Andrew

doi:10.2337/dc16-0645

Public

Systematic Population Screening, Using Biomarkers and Genetic Testing, Identifies 2.5% of the U.K. Pediatric Diabetes Population With Monogenic Diabetes

Published in Diabetes Care • Jun 6, 2016

Authors:

Maggie Shepherd

Beverley M. Shields

Suzanne Hammersley

Abstract

OBJECTIVE: Monogenic diabetes is rare but is an important diagnosis in pediatric diabetes clinics. These patients are often not identified as this relies on the recognition of key clinical features by an alert clinician. Biomarkers (islet autoantibodies and C-peptide) can assist in the exclusion of ...

Subject

Medicine

Diabetes mellitus

HNF1A

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