Combined use of spatial restraint stress and middle cerebral artery occlusion is a novel model of post-stroke depression in mice

Zhang, Gaocai; Chen, Li; Yang, Lingli; Hua, Xiaodong; Zhou, Beiqun; Miao, Zhigang; Li, Jizhen; Hu, Hua; Namaka, Michael; Kong, Jiming; Xu, Xingshun

doi:10.1038/srep16751

Public

Combined use of spatial restraint stress and middle cerebral artery occlusion is a novel model of post-stroke depression in mice

Published in Scientific Reports • Nov 17, 2015

Authors:

Gaocai Zhang

Li Chen

Lingli Yang

Abstract

Post stroke depression (PSD) is one of the most common complications of ischemic stroke. At present, the underlying mechanisms are unclear, largely because there are no reliable, valid and reproducible animal models of PSD. Here we report a novel animal model of PSD that displays consistent and reli...

Subject

Imipramine

Stroke (engine)

Post-stroke depression

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!