Monoclonal antibody-defined functional epitopes on the adhesion- promoting glycoprotein complex (CDw18) of human neutrophils

Wallis, WJ; Hickstein, DD; Schwartz, BR; June, CH; Ochs, HD; G Beatty, P; Klebanoff, SJ; Harlan, JM

doi:10.1182/blood.v67.4.1007.1007

Public

Monoclonal antibody-defined functional epitopes on the adhesion- promoting glycoprotein complex (CDw18) of human neutrophils

Shared by NobleBlocks on Apr 1, 1986 • 12:00 AM UTC

Authors:

WJ Wallis

DD Hickstein

BR Schwartz

Abstract

We have evaluated the functional and immunochemical activities of three monoclonal antibodies (MoAbs) minimally reactive with adherence-defective neutrophils (PMN) from a patient with recurrent bacterial infections. In studies with normal PMN, MoAbs OKM1 and 60.1 both precipitate the same 165kd alph...

Subject

Epitope

Monoclonal antibody

Glycoprotein

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