Novel multiple sclerosis susceptibility loci implicated in epigenetic regulation

F. M. Andlauer, Till; Buck, Dorothea; Antony, Gisela; Bayas, Antonios; Bechmann, Lukas; Berthele, Achim; T. Chan, Andrew; Gasperi, Christiane; Gold, Ralf; Graetz, Christiane; Haas, Jürgen; Hecker, Michael; Infante‐Duarte, Carmen; Knop, Matthias; Kümpfel, Tania; Limmroth, Volker; A. Linker, Ralf; Loleit, Verena; Luessi, Felix; G. Meuth, Sven; Mühlau, Mark; Nischwitz, Sandra; Paul, Friedemann; Pütz, Michael; Ruck, Tobias; Salmen, Anke; Stangel, Martin; Stellmann, Jan‐Patrick; Hanja Stürner, Klarissa; Tackenberg, Björn; Then Bergh, Florian; Tumani, Hayrettin; Warnke, Clemens; Weber, Frank; Wiendl, Heinz; Wildemann, Brigitte; K. Zettl, Uwe; Ziemann, Ulf; Zipp, Frauke; Arloth, Janine; Weber, Peter; Radivojkov‐Blagojevic, Milena; O. Scheinhardt, Markus; Dankowski, Theresa; Bettecken, Thomas; Lichtner, Peter; Czamara, Darina; Carrillo‐Roa, Tania; B. Binder, Elisabeth; Berger, Klaus; Bertram, Lars; Franke, André; Gieger, Christian; Herms, Stefan; Homuth, Georg; Ising, Marcus; Jöckel, Karl‐Heinz; Kacprowski, Tim; Kloiber, Stefan; Laudes, Matthias; Lieb, Wolfgang; M. Lill, Christina; Lucae, Susanne; Meitinger, Thomas; Moebus, Susanne; Müller‐Nurasyid, Martina; M. Nöthen, Markus; Petersmann, Astrid; Rawal, Rajesh; Schminke, Ulf; Strauch, Konstantin; Völzke, Henry; Waldenberger, Mélanie; Wellmann, Jürgen; Porcu, Eleonora; Mulas, Antonella; Pitzalis, Maristella; Sidore, Carlo; Zara, Ilenia; Cucca, Francesco; Żołędziewska, Magdalena; Ziegler, Andreas; Hemmer, Bernhard; Müller‐Myhsok, Bertram

doi:10.1126/sciadv.1501678

Public

Novel multiple sclerosis susceptibility loci implicated in epigenetic regulation

Published in Science Advances • Jun 3, 2016

Authors:

Till F. M. Andlauer

Dorothea Buck

Gisela Antony

Abstract

We conducted a genome-wide association study (GWAS) on multiple sclerosis (MS) susceptibility in German cohorts with 4888 cases and 10,395 controls. In addition to associations within the major histocompatibility complex (MHC) region, 15 non-MHC loci reached genome-wide significance. Four of these l...

Subject

Multiple sclerosis

Epigenetics

Gene

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