Circulating tumor DNA analysis detects minimal residual disease and predicts recurrence in patients with stage II colon cancer

Tie, Jeanne; Wang, Yuxuan; Tomasetti, Cristian; Li, Lu; Springer, Simeon; Kinde, Isaac; Silliman, Natalie; Tacey, Mark; Wong, Hui‐Li; Christie, Michael; Kosmider, Suzanne; Skinner, Iain; Wong, Rachel; Steel, Malcolm; Tran, Ben; Desai, Jayesh; T. Jones, Ian; Haydon, Andrew; Hayes, Theresa; Price, Timothy; L. Strausberg, Robert; A. Díaz, Luis; Papadopoulos, Nickolas; W. Kinzler, Kenneth; Vogelstein, Bert; Gibbs, Peter

doi:10.1126/scitranslmed.aaf6219

Public

Circulating tumor DNA analysis detects minimal residual disease and predicts recurrence in patients with stage II colon cancer

Published in Science Translational Medicine • Jul 6, 2016

Authors:

Jeanne Tie

Yuxuan Wang

Cristian Tomasetti

Abstract

Detection of circulating tumor DNA (ctDNA) after resection of stage II colon cancer may identify patients at the highest risk of recurrence and help inform adjuvant treatment decisions. We used massively parallel sequencing-based assays to evaluate the ability of ctDNA to detect minimal residual dis...

Subject

Colorectal cancer

Stage (stratigraphy)

Minimal residual disease

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