Hydrogen Sulfide Induces Keap1 S-sulfhydration and Suppresses Diabetes-Accelerated Atherosclerosis via Nrf2 Activation

Xie, Liping; Gu, Yue; Wen, Mingliang; Zhao, Shuang; Wang, Wan; Ma, Yan; Meng, Guoliang; Han, Yi; Wang, Yuhui; Liu, Chaojie; K. Moore, Philip; Wang, Xin; Wang, Hong; Zhang, Zhi‐Ren; Yu, Ying; Ferro, Albert; Huang, Zhengrong; Ji, Yong

doi:10.2337/db16-0020

Public

Hydrogen Sulfide Induces Keap1 S-sulfhydration and Suppresses Diabetes-Accelerated Atherosclerosis via Nrf2 Activation

Published in Diabetes • Jun 22, 2016

Authors:

Liping Xie

Yue Gu

Mingliang Wen

Abstract

Hydrogen sulfide (H2S) has been shown to have powerful antioxidative and anti-inflammatory properties that can regulate multiple cardiovascular functions. However, its precise role in diabetes-accelerated atherosclerosis remains unclear. We report here that H2S reduced aortic atherosclerotic plaque ...

Subject

KEAP1

Oxidative stress

Chemistry

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