Olanzapine for the Prevention of Chemotherapy-Induced Nausea and Vomiting

M. Navari, Rudolph; Qin, Rui; J. Ruddy, Kathryn; Liu, Heshan; Powell, Steven; Bajaj, Madhuri; L. Dietrich, Leah; D. Biggs, David; M. Lafky, Jacqueline; L. Loprinzi, Charles

doi:10.1056/nejmoa1515725

Public

Olanzapine for the Prevention of Chemotherapy-Induced Nausea and Vomiting

Published in New England Journal of Medicine • Jul 14, 2016

Authors:

Rudolph M. Navari

Rui Qin

Kathryn J. Ruddy

Abstract

BACKGROUND: We examined the efficacy of olanzapine for the prevention of nausea and vomiting in patients receiving highly emetogenic chemotherapy. METHODS: In a randomized, double-blind, phase 3 trial, we compared olanzapine with placebo, in combination with dexamethasone, aprepitant or fosaprepitan...

Subject

Olanzapine

Medicine

Nausea

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