A whole-genome sequence and transcriptome perspective on HER2-positive breast cancers

Ferrari, Anthony; Vincent‐Salomon, Anne; Pivot, Xavier; Sertier, Anne-Sophie; Thomas, Emilie; Tonon, Laurie; Boyault, Sandrine; Mulugeta, Eskeatnaf; Treilleux, Isabelle; MacGrogan, Gaëtan; Arnould, Laurent; Kielbassa, Janice; Le Texier, Vincent; Blanché, Hélène; Deleuze, Jean‐François; Jacquemier, Jocelyne; Mathieu, Marie‐Christine; Penault‐Llorca, Frédérique; Bibeau, Frédéric; Mariani, Odette; Mannina, Cécile; Pierga, Jean‐Yves; Trédan, Olivier; Bachelot, Thomas; Bonnefoi, Hervé; Romieu, Gilles; Fumoleau, P.; Delaloge, Suzette; Rios, María; Ferrero, Jean-­Marc; Tarpin, Carole; Bouteille, C.; Calvo, Fabien; Gut, Marta; Gut, Marta; Martin, Sancha; Nik‐Zainal, Serena; R. Stratton, Michael; Pauporté, Iris; Saintigny, Pierre; Birnbaum, Daniel; Viari, Alain; Thomas, Gilles

doi:10.1038/ncomms12222

Public

A whole-genome sequence and transcriptome perspective on HER2-positive breast cancers

Published in Nature Communications • Jul 13, 2016

Authors:

Anthony Ferrari

Anne Vincent‐Salomon

Xavier Pivot

Abstract

HER2-positive breast cancer has long proven to be a clinically distinct class of breast cancers for which several targeted therapies are now available. However, resistance to the treatment associated with specific gene expressions or mutations has been observed, revealing the underlying diversity of...

Subject

Breast cancer

Amplicon

Transcriptome

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