Prophylactic radiotherapy for the prevention of procedure-tract metastases after surgical and large-bore pleural procedures in malignant pleural mesothelioma (SMART): a multicentre, open-label, phase 3, randomised controlled trial

Clive, Amelia; Taylor, Hazel; Dobson, Lee; Wilson, Paula; De Winton, Emma; Panakis, N.; Pepperell, Justin; Howell, Timothy; A. Stewart, Samuel; Penz, Erika; N. Jordan, Nikki; J. Morley, Anna; Zahan-Evans, Natalie; Smith, Sarah; Batchelor, Tim; Marchbank, Adrian; Bishop, Lesley; Ionescu, Alina; Bayne, Mike; Cooper, Samantha; Kerry, Anthony; Jenkins, Peter; Toy, Elizabeth; Vigneswaran, Vallipuram; Gildersleve, J.; Ahmed, Merina; McDonald, Fiona; Button, Mick; Lewanski, C.; Comins, Charles; Dakshinamoorthy, Muthukumar; Lee, Gary; M. Rahman, Najib; Maskell, Nick

doi:10.1016/s1470-2045(16)30095-x

Public

Prophylactic radiotherapy for the prevention of procedure-tract metastases after surgical and large-bore pleural procedures in malignant pleural mesothelioma (SMART): a multicentre, open-label, phase 3, randomised controlled trial

Published in The Lancet Oncology • Jun 25, 2016

Authors:

Amelia Clive

Hazel Taylor

Lee Dobson

Abstract

BACKGROUND: The use of prophylactic radiotherapy to prevent procedure-tract metastases (PTMs) in malignant pleural mesothelioma remains controversial, and clinical practice varies worldwide. We aimed to compare prophylactic radiotherapy with deferred radiotherapy (given only when a PTM developed) in...

Subject

Medicine

Radiation therapy

Mesothelioma

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