Umbilical Cord-Derived Mesenchymal Stem Cell-Derived Exosomal MicroRNAs Suppress Myofibroblast Differentiation by Inhibiting the Transforming Growth Factor-β/SMAD2 Pathway During Wound Healing

Fang, Shuo; Xu, Chen; Zhang, Yuntong; Xue, Chunyu; Yang, Chao; Bi, Hongda; Qian, Xijing; Wu, Minjuan; Ji, Kaihong; Zhao, Yunpeng; Wang, Yue; Liu, Houqi; Xing, Xin

doi:10.5966/sctm.2015-0367

Public

Umbilical Cord-Derived Mesenchymal Stem Cell-Derived Exosomal MicroRNAs Suppress Myofibroblast Differentiation by Inhibiting the Transforming Growth Factor-β/SMAD2 Pathway During Wound Healing

Published in Stem Cells Translational Medicine • Jul 7, 2016

Authors:

Shuo Fang

Chen Xu

Yuntong Zhang

Abstract

: Excessive scar formation caused by myofibroblast aggregations is of great clinical importance during skin wound healing. Studies have shown that mesenchymal stem cells (MSCs) can promote skin regeneration, but whether MSCs contribute to scar formation remains undefined. We found that umbilical cor...

Subject

Microvesicles

Mesenchymal stem cell

Myofibroblast

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