MAIT cells are activated during human viral infections

van Wilgenburg, Bonnie; Scherwitzl, Iris; Hutchinson, Edward; Leng, Tianqi; Kurioka, Ayako; A. Kulicke, Corinna; de Lara, Catherine; Cole, Suzanne; Vasanawathana, Sirijitt; Limpitikul, Wannee; Malasit, Prida; Young, Duncan; Denney, Laura; Barnes, Eleanor; K. Ball, Jonathan; Burgess, Gary; Cooke, G; Dillon, John; Gore, Charles; R. Foster, Graham; Guha, Neil; Halford, Rachel; Herath, Cham; Holmes, Christopher; Y. M. Howe, Anita; Hudson, Emma; L. Irving, William; I. Khakoo, Salim; Koletzki, Diana; K. Martin, Natasha; Mbisa, Tamyo; A. McKeating, Jane; McLauchlan, John; Miners, Alec; Murray, Andrea; Shaw, Peter; Simmonds, Peter; C. A. Spencer, Chris; Targett‐Adams, Paul; C. Thomson, Emma; Vickerman, Peter; Zitzmann, Nicole; Moore, Michael; Fabris, Paolo; Teresa Giordani, Maria; Htun Oo, Ye; M. Laidlaw, Stephen; B. Dustin, Lynn; Ho, Ling‐Pei; M. Thompson, Fiona; Ramamurthy, Narayan; Mongkolsapaya, Juthathip; B. Willberg, Christian; Screaton, Gavin; Klenerman, Paul

doi:10.1038/ncomms11653

Public

MAIT cells are activated during human viral infections

Published in Nature Communications • Jun 23, 2016

Authors:

Bonnie van Wilgenburg

Iris Scherwitzl

Edward Hutchinson

Abstract

Mucosal-associated invariant T (MAIT) cells are abundant in humans and recognize bacterial ligands. Here, we demonstrate that MAIT cells are also activated during human viral infections in vivo. MAIT cells activation was observed during infection with dengue virus, hepatitis C virus and influenza vi...

Subject

Dengue virus

Immunology

Hepatitis C virus

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