MAIT cells are activated during human viral infections

van Wilgenburg, Bonnie; Scherwitzl, Iris; C. Hutchinson, Edward; Leng, Tianqi; Kurioka, Ayako; Kulicke, Corinna; de Lara, Catherine; Cole, Suzanne; Vasanawathana, Sirijitt; Limpitikul, Wannee; Malasit, Prida; Young, Duncan; Denney, Laura; consortium, STOP-HCV; Barnes, Eleanor; Ball, Jonathan; Burgess, Gary; Cooke, Graham; Dillon, John; Gore, Charles; Foster, Graham; Guha, Neil; Halford, Rachel; Herath, Cham; Holmes, Chris; Howe, Anita; Hudson, Emma; Irving, William; Khakoo, Salim; Koletzki, Diana; Martin, Natasha; Mbisa, Tamyo; McKeating, Jane; McLauchlan, John; Miners, Alec; Murray, Andrea; Shaw, Peter; Simmonds, Peter; Spencer, Chris; Targett-Adams, Paul; Thomson, Emma; Vickerman, Peter; Zitzmann, Nicole; D. Moore, Michael; Fabris, Paolo; Teresa Giordani, Maria; Htun Oo, Ye; M. Laidlaw, Stephen; B. Dustin, Lynn; Ho, Ling-Pei; M. Thompson, Fiona; Ramamurthy, Narayan; Mongkolsapaya, Juthathip; B. Willberg, Christian; R. Screaton, Gavin; Klenerman, Paul

doi:10.1038/ncomms11653

Public

MAIT cells are activated during human viral infections

Shared by NobleBlocks on Jun 23, 2016 • 12:00 AM UTC

Authors:

Bonnie van Wilgenburg

Iris Scherwitzl

Edward C. Hutchinson

Abstract

Abstract Mucosal-associated invariant T (MAIT) cells are abundant in humans and recognize bacterial ligands. Here, we demonstrate that MAIT cells are also activated during human viral infections in vivo . MAIT cells activation was observed during infection with dengue virus, hepatitis C virus and in...

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