Dual Inhibition of PI3K/Akt and mTOR by the Dietary Antioxidant, Delphinidin, Ameliorates Psoriatic Features In Vitro and in an Imiquimod-Induced Psoriasis-Like Disease in Mice

Christopher Chamcheu, Jean; M. Adhami, Vaqar; Esnault, Stéphane; Sechi, Mario; A. Siddiqui, Imtiaz; A. Satyshur, Kenneth; N. Syed, Deeba; M. Dodwad, Shah-Jahan; Chaves-Rodriquez, Maria-Ines; Jack Longley, B.; S. Wood, Gary; Mukhtar, Hasan

doi:10.1089/ars.2016.6769

Public

Dual Inhibition of PI3K/Akt and mTOR by the Dietary Antioxidant, Delphinidin, Ameliorates Psoriatic Features In Vitro and in an Imiquimod-Induced Psoriasis-Like Disease in Mice

Published in Antioxidants and Redox Signaling • Jul 9, 2016

Authors:

Jean Christopher Chamcheu

Vaqar M. Adhami

Stéphane Esnault

Abstract

AIM: The treatment of psoriasis remains elusive, underscoring the need for identifying novel disease targets and mechanism-based therapeutic approaches. We recently reported that the PI3K/Akt/mTOR pathway that is frequently deregulated in many malignancies is also clinically relevant for psoriasis. ...

Subject

PI3K/AKT/mTOR pathway

Protein kinase B

Psoriasis

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