Specificity, cross-reactivity, and function of antibodies elicited by Zika virus infection

Stettler, Karin; Beltramello, Martina; A. Espinosa, Diego; Graham, Victoria; Cassotta, Antonino; Bianchi, Siro; Vanzetta, Fabrizia; Minola, Andrea; Jaconi, Stefano; Mele, Federico; Foglierini, Mathilde; Pedotti, Mattia; Simonelli, Luca; Dowall, Stuart; Atkinson, Barry; Percivalle, Elena; P. Simmons, Cameron; Varani, Luca; Blum, Johannes; Baldanti, Fausto; Cameroni, Elisabetta; Hewson, Roger; Harris, Eva; Lanzavecchia, Antonio; Sallusto, Federica; Corti, Davide

doi:10.1126/science.aaf8505

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Specificity, cross-reactivity, and function of antibodies elicited by Zika virus infection

Published in Science • Jul 14, 2016

Authors:

Karin Stettler

Martina Beltramello

Diego A. Espinosa

Abstract

Zika virus (ZIKV), a mosquito-borne flavivirus with homology to Dengue virus (DENV), has become a public health emergency. By characterizing memory lymphocytes from ZIKV-infected patients, we dissected ZIKV-specific and DENV-cross-reactive immune responses. Antibodies to nonstructural protein 1 (NS1...

Subject

Zika virus

Virology

Dengue virus

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