Activation of STING requires palmitoylation at the Golgi

Mukai, Kojiro; Konno, Hiroyasu; Akiba, Tatsuya; Uemura, Takefumi; Waguri, Satoshi; Kobayashi, Toshihide; N. Barber, Glen; Arai, Hiroyuki; Taguchi, Tomohiko

doi:10.1038/ncomms11932

Public

Activation of STING requires palmitoylation at the Golgi

Published in Nature Communications • Jun 21, 2016

Authors:

Kojiro Mukai

Hiroyasu Konno

Tatsuya Akiba

Abstract

Stimulator of interferon genes (STING) is essential for the type I interferon response against DNA pathogens. In response to the presence of DNA and/or cyclic dinucleotides, STING translocates from the endoplasmic reticulum to perinuclear compartments. However, the role of this subcellular transloca...

Subject

Sting

Palmitoylation

Stimulator of interferon genes

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