GATA6 regulates EMT and tumour dissemination, and is a marker of response to adjuvant chemotherapy in pancreatic cancer

Martinelli, Paola; Carrillo de Santa Pau, Enrique; F. Cox, Trevor; Sáinz, Bruno; Dusetti, Nelson; Greenhalf, William; Rinaldi, Lorenzo; Costello, Eithne; Ghaneh, Paula; Malats, Núria; W. Büchler, Markus; Pajic, Marina; V. Biankin, Andrew; Iovanna, Juan; P. Neoptolemos, John; X. Real, Francisco

doi:10.1136/gutjnl-2015-311256

Public

GATA6 regulates EMT and tumour dissemination, and is a marker of response to adjuvant chemotherapy in pancreatic cancer

Published in Gut • Jun 20, 2016

Authors:

Paola Martinelli

Enrique Carrillo de Santa Pau

Trevor F. Cox

Abstract

Background and aims The role of GATA factors in cancer has gained increasing attention recently, but the function of GATA6 in pancreatic ductal adenocarcinoma (PDAC) is controversial. GATA6 is amplified in a subset of tumours and was proposed to be oncogenic, but high GATA6 levels are found in well-...

Subject

GATA6

Cancer research

Biology

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