The human platelet as a pharmacologic model for the adrenergic neuron

The uptake of norepinephrine (NE) by the human platelet resembles that of the adrenergic neuron. Platelets incubated with d1‐ 14 C‐NE (2.1 x 10 −6 M) for one hour at 37° C. concentrated the amine to a distribution ratio of 5.1 ± 0.1. Uptake was markedly reduced by cold and metabolic inhibitors such ... View More