Visualization and analysis of gene expression in tissue sections by spatial transcriptomics

L. Ståhl, Patrik; Salmén, Fredrik; Vicković, Sanja; Lundmark, Anna; Fernández Navarro, José; P. Magnusson, Jens; Giacomello, Stefania; Asp, Michaela; Orzechowski Westholm, Jakub; Huss, Mikael; Mollbrink, Annelie; Linnarsson, Sten; Codeluppi, Simone; Borg, Åke; Pontén, Fredrik; Igor Costea, Paul; Sahlén, Pelin; Mulder, Jan; Bergmann, Olaf; Lundeberg, Joakim; Frisén, Jonas

doi:10.1126/science.aaf2403

Public

Visualization and analysis of gene expression in tissue sections by spatial transcriptomics

Published in Science • Jun 30, 2016

Authors:

Patrik L. Ståhl

Fredrik Salmén

Sanja Vicković

Abstract

Analysis of the pattern of proteins or messengerRNAs (mRNAs) in histological tissue sections is a cornerstone in biomedical research and diagnostics. This typically involves the visualization of a few proteins or expressed genes at a time. We have devised a strategy, which we call "spatial transcrip...

Subject

Computational biology

Gene

Transcriptome

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