De Novo Prediction of Stem Cell Identity using Single-Cell Transcriptome Data

Grün, Dominic; J. Muraro, Mauro; Boisset, Jean-Charles; Wiebrands, Kay; Lyubimova, Anna; Dharmadhikari, Gitanjali; van den Born, Maaike; H. van Es, Johan; W.L. Jansen, Erik; Clevers, Hans; J.P. de Koning, Eelco; van Oudenaarden, Alexander

doi:10.1016/j.stem.2016.05.010

Public

De Novo Prediction of Stem Cell Identity using Single-Cell Transcriptome Data

Published in Cell stem cell • Jun 25, 2016

Authors:

Dominic Grün

Mauro J. Muraro

Jean-Charles Boisset

Abstract

Adult mitotic tissues like the intestine, skin, and blood undergo constant turnover throughout the life of an organism. Knowing the identity of the stem cell is crucial to understanding tissue homeostasis and its aberrations upon disease. Here we present a computational method for the derivation of ...

Subject

Biology

Stem cell

Transcriptome

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