ABCB1 (MDR1) induction defines a common resistance mechanism in paclitaxel- and olaparib-resistant ovarian cancer cells

Vaidyanathan, Aparajitha; Sawers, Lynne; Gannon, Anne‐Louise; Chakravarty, Probir; Scott, Alison; E. Bray, Susan; Ferguson, Michelle; Smith, Gillian

doi:10.1038/bjc.2016.203

Public

ABCB1 (MDR1) induction defines a common resistance mechanism in paclitaxel- and olaparib-resistant ovarian cancer cells

Published in British Journal of Cancer • Jul 14, 2016

Authors:

Aparajitha Vaidyanathan

Lynne Sawers

Anne‐Louise Gannon

Abstract

BACKGROUND: Clinical response to chemotherapy for ovarian cancer is frequently compromised by the development of drug-resistant disease. The underlying molecular mechanisms and implications for prescription of routinely prescribed chemotherapy drugs are poorly understood. METHODS: We created novel A...

Subject

Olaparib

Paclitaxel

Veliparib

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