Exosomes derived from human embryonic mesenchymal stem cells promote osteochondral regeneration

Zhang, Shipin; Cui Chu, Wern; Chai Lai, Ruenn; Kiang Lim, Sai; Hoi Po Hui, James; Seong Toh, Wei

doi:10.1016/j.joca.2016.06.022

Public

Exosomes derived from human embryonic mesenchymal stem cells promote osteochondral regeneration

Published in Osteoarthritis and Cartilage • Jul 5, 2016

Authors:

Shipin Zhang

Wern Cui Chu

Ruenn Chai Lai

Abstract

OBJECTIVE: Clinical and animal studies have demonstrated the efficacy of mesenchymal stem cell (MSC) therapies in cartilage repair. As the efficacy of many MSC-based therapies has been attributed to paracrine secretion, particularly extracellular vesicles/exosomes, we determine here if weekly intra-...

Subject

Mesenchymal stem cell

Cartilage

Microvesicles

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