ALS/FTD‐associated FUS activates GSK‐3β to disrupt the VAPB–PTPIP51 interaction and ER–mitochondria associations

Stoica, Radu; Paillusson, Sébastien; Gómez‐Suaga, Patricia; C. Mitchell, Jacqueline; H. W. Lau, Dawn; H. Gray, Emma; M. Sancho, Rosa; Vizcay‐Barrena, Gema; J. De Vos, Kurt; E. Shaw, Christopher; P. Hanger, Diane; Noble, Wendy; C.J. Miller, Christopher

doi:10.15252/embr.201541726

Public

ALS/FTD‐associated FUS activates GSK‐3β to disrupt the VAPB–PTPIP51 interaction and ER–mitochondria associations

Published in EMBO Reports • Jul 14, 2016

Authors:

Radu Stoica

Sébastien Paillusson

Patricia Gómez‐Suaga

Abstract

Defective FUS metabolism is strongly associated with amyotrophic lateral sclerosis and frontotemporal dementia (ALS/FTD), but the mechanisms linking FUS to disease are not properly understood. However, many of the functions disrupted in ALS/FTD are regulated by signalling between the endoplasmic ret...

Subject

Clinical neuroscience

Neuroscience

Library science

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