Microbial biotransformation of DON: molecular basis for reduced toxicity

Pierron, Alix; Mimoun, Sabria; Sayuri Murate, Letı́cia; Loiseau, Nicolas; Lippi, Yannick; Paula Frederico Rodrigues Loureiro Bracarense, Ana; Schatzmayr, Gerd; He, Jian; Zhou, Ting; Moll, W.; P. Oswald, Isabelle

doi:10.1038/srep29105

Public

Microbial biotransformation of DON: molecular basis for reduced toxicity

Published in Scientific Reports • Jul 6, 2016

Authors:

Alix Pierron

Sabria Mimoun

Letı́cia Sayuri Murate

Abstract

Bacteria are able to de-epoxidize or epimerize deoxynivalenol (DON), a mycotoxin, to deepoxy-deoxynivalenol (deepoxy-DON or DOM-1) or 3-epi-deoxynivalenol (3-epi-DON), respectively. Using different approaches, the intestinal toxicity of 3 molecules was compared and the molecular basis for the reduce...

Subject

Biotransformation

Toxicity

Explant culture

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