Targeting CD73 in the tumor microenvironment with MEDI9447

Hay, Carl; Sult, Erin; Huang, Qihui; Mulgrew, Kathy; Fuhrmann, Stacy; McGlinchey, Kelly; A. Hammond, Scott; Rothstein, Raymond; Rios‐Doria, Jonathan; Poon, Edmund; Holoweckyj, Nick; M. Durham, Nicholas; Ching Leow, Ching; Diedrich, Gundo; Damschroder, Melissa; Herbst, Ronald; E. Hollingsworth, Robert; F. Sachsenmeier, Kris

doi:10.1080/2162402x.2016.1208875

Public

Targeting CD73 in the tumor microenvironment with MEDI9447

Published in OncoImmunology • Jul 11, 2016

Authors:

Carl Hay

Erin Sult

Qihui Huang

Abstract

MEDI9447 is a human monoclonal antibody that is specific for the ectoenzyme CD73 and currently undergoing Phase I clinical trials. Here we show that MEDI9447 is a potent inhibitor of CD73 ectonucleotidase activity, with wide ranging immune regulatory consequences. MEDI9447 results in relief from ade...

Subject

Tumor microenvironment

Cancer research

Cancer immunotherapy

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