Randomized Trial of Thymectomy in Myasthenia Gravis

I. Wolfe, Gil; J. Kaminski, Henry; Aban, Inmaculada; Minisman, Greg; Kuo, Hui‐Chien; Marx, Alexander; Ströbel, Philipp; Mazia, Claudio; Oger, Joël; Cea, Gabriel; M. Heckmann, Jeannine; Evoli, Amelia; A. Nix, Wilfred; Ciafaloni, Emma; Antonini, Giovanni; Witoonpanich, Rawiphan; King, John; R. Beydoun, Said; Chalk, Colin; Barboi, Alexandru; A. Amato, Anthony; Shaibani, Aziz; Katirji, Bashar; Lecky, Bryan; Buckley, Camilla; Vincent, Angela; Dias‐Tosta, Elza; Yoshikawa, Hiroaki; Waddington‐Cruz, Márcia; Pulley, Michael; H. Rivner, Michael; Kostera‐Pruszczyk, Anna; M. Pascuzzi, Robert; E. Jackson, Carlayne; Ramos, Guillermo; J.G.M. Verschuuren, Jan; M. Massey, Janice; T. Kissel, John; César Werneck, Lineu; Benatar, Michael; J. Barohn, Richard; Tandan, Rup; Mozaffar, Tahseen; Conwit, Robin; Odenkirchen, Joanne; Sonett, Joshua; Jaretzki, Alfred; Newsom–Davis, John; Cutter, Gary

doi:10.1056/nejmoa1602489

Public

Randomized Trial of Thymectomy in Myasthenia Gravis

Published in New England Journal of Medicine • Aug 10, 2016

Authors:

Gil I. Wolfe

Henry J. Kaminski

Inmaculada Aban

Abstract

BACKGROUND: Thymectomy has been a mainstay in the treatment of myasthenia gravis, but there is no conclusive evidence of its benefit. We conducted a multicenter, randomized trial comparing thymectomy plus prednisone with prednisone alone. METHODS: We compared extended transsternal thymectomy plus al...

Subject

Thymectomy

Prednisone

Myasthenia gravis

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