ROCK2 signaling is required to induce a subset of T follicular helper cells through opposing effects on STATs in autoimmune settings

M. Weiss, Jonathan; Chen, Wei; Nyuydzefe, Melanie; Trzeciak, Alissa; Flynn, Ryan; R. Tonra, James; Marušić, Suzana; R. Blazar, Bruce; D. Waksal, Samuel; Zanin‐Zhorov, Alexandra

doi:10.1126/scisignal.aad8953

Public

ROCK2 signaling is required to induce a subset of T follicular helper cells through opposing effects on STATs in autoimmune settings

Published in Science Signaling • Jul 19, 2016

Authors:

Jonathan M. Weiss

Wei Chen

Melanie Nyuydzefe

Abstract

Rho-associated kinase 2 (ROCK2) determines the balance between human T helper 17 (TH17) cells and regulatory T (Treg) cells. We investigated its role in the generation of T follicular helper (TFH) cells, which help to generate antibody-producing B cells under normal and autoimmune conditions. Inhibi...

Subject

BCL6

STAT5

Germinal center

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