Oxidized Phospholipids on Lipoprotein(a) Elicit Arterial Wall Inflammation and an Inflammatory Monocyte Response in Humans

M. van der Valk, Fleur; Bekkering, Siroon; Kroon, Jeffrey; Yeang, Calvin; Van den Bossche, Jan; D. van Buul, Jaap; Ravandi, Amir; J. Nederveen, Aart; J. Verberne, Hein; A. Scipione, Corey; Nieuwdorp, Max; A. B. Joosten, Leo; G. Netea, Mihai; L. Koschinsky, Marlys; L. Witztum, Joseph; Tsimikas, Sotirios; P. Riksen, Niels; S.G. Stroes, Erik

doi:10.1161/circulationaha.116.020838

Public

Oxidized Phospholipids on Lipoprotein(a) Elicit Arterial Wall Inflammation and an Inflammatory Monocyte Response in Humans

Published in Circulation • Aug 6, 2016

Authors:

Fleur M. van der Valk

Siroon Bekkering

Jeffrey Kroon

Abstract

BACKGROUND: Elevated lipoprotein(a) [Lp(a)] is a prevalent, independent cardiovascular risk factor, but the underlying mechanisms responsible for its pathogenicity are poorly defined. Because Lp(a) is the prominent carrier of proinflammatory oxidized phospholipids (OxPLs), part of its atherothrombos...

Subject

Proinflammatory cytokine

Inflammation

Medicine

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