Pericyte–fibroblast transition promotes tumor growth and metastasis

Hosaka, Kayoko; Yang, Yunlong; Seki, Takahiro; Fischer, Carina; Dubey, Olivier; Fredlund, Erik; Hartman, Johan; Religa, Piotr; Morikawa, Hiromasa; Ishii, Yoko; Sasahara, Masakiyo; Larsson, Ola; Cossu, Giulio; Cao, Renhai; Lim, Sharon; Cao, Yihai

doi:10.1073/pnas.1608384113

Public

Pericyte–fibroblast transition promotes tumor growth and metastasis

Published in Proceedings of the National Academy of Sciences • Sep 7, 2016

Authors:

Kayoko Hosaka

Yunlong Yang

Takahiro Seki

Abstract

Vascular pericytes, an important cellular component in the tumor microenvironment, are often associated with tumor vasculatures, and their functions in cancer invasion and metastasis are poorly understood. Here we show that PDGF-BB induces pericyte-fibroblast transition (PFT), which significantly co...

Subject

Pericyte

Transition (genetics)

Metastasis

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